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| Sampannang,Apichakan; Arun,Supatcharee; Sukhorum,Wannisa; Burawat,Jaturon; Nualkaew,Somsak; Maneenin,Chanwit; Sripanidkulchai,Bungorn; Iamsaard,Sitthichai. |
| The aim of present study was to investigate the effect of Momordica cochinchinensis (Gag) aril (GA) aqueous extract on male reproductive system of streptozotocin (STZ)-induced hyperglycemia (HG) mice. GA were extracted with distilled water (DW) and analyzed for in vitro antioxidant capacities. ICR male mice were divided into 7 groups: 1) control, 2) DW, 3) GA 1000 mg/kg BW, 4) HG, 5) HG + glibenclamide, 6 and 7) HG + GA 500 and 1000 mg/kg BW respectively (7 mice/ group). In HG groups, mice were induced by STZ at single dose (150 mg/kg BW). They were treated for consecutive 35 days. All groups were compared for blood glucose levels, weights and histopathologies of reproductive organs, sperm concentration including testicular tyrosine phosphorylation protein... |
| Tipo: Journal article |
Palavras-chave: Momordica cochinchinensis aril; Streptozotocin (STZ); Testicular damage; Testicular tyrosine phosphorylated protein; Hyperglycemia (HG) mice. |
| Ano: 2017 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200046 |
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| Sukhorum,Wannisa; Sampannang,Apichakarn; Sripanidkulchai,Bungorn; Iamsaard,Sitthichai. |
| This study aimed to investigate protective effect of Momordica cochinchinensis (MC) aril extract on adverse reproductive parameters of male rat induced with valproic acid (VPA) commonly used in treatment for antiepileptic diseases. Male Wistar rats were divided into 6 groups (control, VPA, 200 mg/kg BW of PE only, and 50, 100, 200 mg/kg BW MC+VPA, respectively). Animals were pretreated with aqueous MC extract for 23 days before co-administered with VPA induction for 10 days. At the end of experiment, all male reproductive parameters and testicular histology were examined. The results showed all doses of PE significantly protect the decrease the weights of epididymis and seminal vesicle but not of body and testicular weights. MC extract also increased sperm... |
| Tipo: Journal article |
Palavras-chave: Momordica cochinchinensis; Valproic acid; Male reproductive parameters; Testicular damage; Rats. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300009 |
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| Iamsaard,Sitthichai; Arun,Supatcharee; Burawat,Jaturon; Sukhorum,Wannisa; Boonruangsri,Porntip; Namking,Malivalaya; Uabundit,Nongnut; Nualkaew,Somsak; Sripanidkulchai,Bungorn. |
| Valproic acid (VPA), widely used in treating epileptic patients, can damage reproductive parameters causing male infertility. This study aimed to investigate protective effect of Phyllanthus emblica L. branch (PE) extract on rat testicular damage induced with VPA. Male rats were divided into 6 groups (control, VPA, 250 mg/kgBW PE only, and 50, 100, 250 mg/kgBW PE+VPA, respectively). Animals were pretreated with PE for 23 days and co-administered with VPA for 10 days before all reproductive parameters were determined. The results showed all doses of PE significantly protected the decrease testicular weight and testosterone level in VPA rats. PE significantly improved the decrease sperm concentration in VPA treated rats. Moreover, testicular histology of... |
| Tipo: Journal article |
Palavras-chave: Valproic acid; Phyllanthus emblica L; Testicular damage; Rats. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300033 |
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